Musculoskeletal: clinical-trial pipeline
28,933 musculoskeletal trials are in ClinicalTrials.gov and the EU CTIS portal; 6,433 are not yet finished and 321 of those are in phase 2/3 or 3. Source: Arcadium Data, data as of .
Open trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 5,075 |
| Phase 2 | 381 |
| Phase 4 | 320 |
| Phase 3 | 274 |
| Phase 1/2 | 143 |
| Phase 1 | 133 |
| Early phase 1 | 57 |
| Phase 2/3 | 47 |
| Not stated | 3 |
Sponsors with the most open trials
Recently changed open trials
| Registry id | Title | Sponsor | Phase | Status | Countries |
|---|---|---|---|---|---|
| NCT06185764 | A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) | Vertex Pharmaceuticals Incorporated | Phase 1/2 | Active, not recruiting | Australia, Belgium, Canada, Germany +6 |
| NCT05316155 | Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer | Janssen Research & Development, LLC | Phase 1/2 | Active, not recruiting | Canada, Germany, Spain, Israel +4 |
| NCT05169229 | Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement. | University Hospital, Linkoeping | Phase 2 | Not yet recruiting | Denmark, Sweden |
| 2023-507506-14-01 | Comparison of PENG block and lumbar plexus block in terms of postoperative analgesia and mobilization for fas… | Hospital Del Mar | Phase 4 | Recruiting | Spain |
| 2024-510637-18-00 | The effect of denosumab on muscle and strength and insulin sensitivity | Region Midtjylland | Phase 4 | Recruiting | Denmark |
| NCT05966064 | DEnosumab for the Treatment of FIbrous Dysplasia/McCune-Albright Syndrome in Adults (DeFiD) | Leids Universitair Medisch Centrum (LUMC) | Phase 4 | Recruiting | Netherlands |
| 2024-510746-14-00 | Detailed assessment of axial and peripheral entheses and joints in axial spondyloarthritis and psoriatic arth… | Rigshospitalet | Phase 4 | Active, not recruiting | Denmark |
| 2023-506131-15-00 | I4V-MC-JAHX: A Phase 3 Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Pati… | Eli Lilly & Co. | Phase 3 | Recruiting | Austria, Belgium, Czechia, Germany +5 |
| NCT06195540 | RIVAroxaban Versus Low-molecular Weight Heparin in Patients With Lower Limb Trauma Requiring Brace or CASTing | University Hospital, Angers | Phase 3 | Recruiting | France |
| 2023-509181-38-00 | Metformin treatment of patients with hand osteoarthritis: A randomised, placebo-controlled trial | Bispebjerg Hospital | Phase 3 | Active, not recruiting | Denmark |
| NCT05481879 | Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With M… | Dyne Therapeutics | Phase 1/2 | Active, not recruiting | Australia, Germany, France, United Kingdom +4 |
| 2023-509610-11-00 | Hyperbaric Oxygen Therapy in Hamstring injury (HOTHAM) trial | Amsterdam UMC | Phase 3 | Active, not recruiting | Netherlands |
| 2023-508341-40-00 | COACH: A Phase 2, Open-Label, 156-week Trial to Investigate the Efficacy, Safety and Tolerability of Once Wee… | Ascendis Pharma Growth Disorders A/S | Phase 2 | Active, not recruiting | Denmark, Ireland |
| 2023-507714-27-00 | An international, multicentre, interventional, randomised assessor-blinded trial to MAXimise the METHotrexate… | Medical University of Vienna | Phase 4 | Recruiting | Austria, Italy, Netherlands, Norway +2 |
| 2023-506091-27-00 | A Phase 2, Multicenter, Double-Blind, Randomized, Placebo-controlled Trial, evaluating Safety, Tolerability,… | Ascendis Pharma Growth Disorders A/S | Phase 2 | Not yet recruiting | Austria, Germany, Denmark, Spain +7 |
| NCT03424018 | An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia | BioMarin Pharmaceutical | Phase 3 | Active, not recruiting | Australia, Germany, Spain, United Kingdom +2 |
| NCT03199469 | A Study of AT132 in Young Children With X-Linked Myotubular Myopathy (XLMTM) | Astellas Gene Therapies | Phase 2/3 | Active, not recruiting | Canada, Germany, France, United States |
| NCT06211764 | A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invas… | Janssen Research & Development, LLC | Phase 3 | Active, not recruiting | Argentina, Belgium, Brazil, China +10 |
| NCT06497140 | Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2 | Assistance Publique - Hôpitaux de Paris | Phase 3 | Recruiting | France |
| NCT06444919 | Capsaicin in Digital Osteoarthritis Versus Control | University Hospital, Clermont-Ferrand | Phase 4 | Recruiting | France |
All areas: clinical-trial pipeline by sponsor.
Track a sponsor's pipeline
The API returns the same trials by sponsor website, phase, status, condition and country with a change feed, joined to hiring and public contract awards. Try it without a key on one sponsor.
Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "Musculoskeletal clinical trials: 6,433 open, 321 in phase 3", https://arcadiumdata.io/clinical-trials/area/musculoskeletal/, data as of 2026-10-25.