Metabolic and endocrine (diabetes, obesity): clinical-trial pipeline
46,117 metabolic and endocrine (diabetes, obesity) trials are in ClinicalTrials.gov and the EU CTIS portal; 8,439 are not yet finished and 621 of those are in phase 2/3 or 3. Source: Arcadium Data, data as of .
Open trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 5,939 |
| Phase 2 | 720 |
| Phase 3 | 539 |
| Phase 4 | 439 |
| Phase 1 | 417 |
| Phase 1/2 | 185 |
| Early phase 1 | 118 |
| Phase 2/3 | 82 |
Sponsors with the most open trials
Recently changed open trials
| Registry id | Title | Sponsor | Phase | Status | Countries |
|---|---|---|---|---|---|
| NCT05196035 | A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into,… | Bayer | Phase 3 | Active, not recruiting | Argentina, Austria, Australia, Belgium +27 |
| 2023-509819-87-00 | A 52 week prospective randomized controlled study to investigate the effect of intramuscular testosterone und… | Medical University Of Vienna | Phase 4 | Active, not recruiting | Austria |
| NCT06165341 | Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Diseas… | Takeda | Phase 3 | Recruiting | Austria, Belgium, Canada, Switzerland +10 |
| NCT05457283 | A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an AC… | Bayer | Phase 3 | Active, not recruiting | Argentina, Austria, Australia, Belgium +27 |
| 2024-510637-18-00 | The effect of denosumab on muscle and strength and insulin sensitivity | Region Midtjylland | Phase 4 | Recruiting | Denmark |
| 2023-508322-10-00 | A Double-Blind, Placebo-Controlled, Crossover Pilot Study of the Efficacy and Safety of Fluasterone Buccal Ta… | Sterotherapeutics LLC | Phase 2 | Recruiting | Greece |
| 2023-505673-32-00 | A Phase 3, Randomized, Double-blinded, Placebo-controlled, Multicenter Study to Evaluate Efficacy and Safety… | Alexion Pharmaceuticals Inc. | Phase 3 | Active, not recruiting | Austria, Belgium, Germany, Spain +4 |
| 2023-505286-84-00 | Randomized phase 2 trial of two chemotherapy regimens plus or minus bevacizumab in patients with well differe… | Institut Gustave Roussy | Phase 2 | Active, not recruiting | France |
| NCT05284747 | EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Amgen | Phase 4 | Active, not recruiting | Brazil, Sweden, United States |
| NCT03813407 | An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia | AstraZeneca | Phase 3 | Recruiting | Brazil, Canada, China, Germany +9 |
| NCT06140095 | Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism | Region Stockholm | Early phase 1 | Not yet recruiting | Sweden |
| NCT04954820 | Assessment of Retreatment With Lutathera® in Patients With New Progression of Intestinal Well-differenciated… | Institut du Cancer de Montpellier - Val d'Aurelle | Phase 2 | Recruiting | France |
| NCT03157128 | A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tum… | Eli Lilly and Company | Phase 1/2 | Active, not recruiting | Australia, Canada, Switzerland, Germany +12 |
| 2023-508183-29-00 | Effect of Roxadustat on Cardiometabolism | Pohjois-Pohjanmaan hyvinvointialue | Phase 4 | Active, not recruiting | Finland |
| 2023-507348-35-00 | Anti-viral action against Type 1 diabetes autoimmunity GPPAD-05-AVAnT1A | Klinikum rechts der Isar der TU Muenchen AöR | Phase 4 | Recruiting | Austria, Belgium, Germany, Italy +2 |
| NCT04537377 | A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease | Vivet Therapeutics SAS | Phase 1/2 | Active, not recruiting | Germany, Denmark, United Kingdom, United States |
| 2024-513168-24-00 | A randomised, controlled, parallel group, open-label trial evaluating the impact of treatment with the GLP-1… | University College Dublin | Phase 2 | Recruiting | Denmark, Ireland, Italy |
| 2022-500306-17-00 | A multi-center, randomized, active controlled clinical trial to evaluate the efficacy and safety of OTL-203 i… | Orchard Therapeutics (Europe) Limited | Phase 3 | Active, not recruiting | Italy, Netherlands |
| NCT05957991 | Danish Precocious Puberty Study - DAPP Study A National Cohort Study on Incidence and Etiologies for Precocio… | Copenhagen University Hospital at Herlev | Not applicable | Recruiting | Denmark |
| NCT06562361 | A Microdose Trial Investigating Binding of [68Ga]Ga-DOTA-CYS-ATH001 in Healthy Subjects and Different Patient… | Antaros Medical | Early phase 1 | Recruiting | Sweden |
All areas: clinical-trial pipeline by sponsor.
Track a sponsor's pipeline
The API returns the same trials by sponsor website, phase, status, condition and country with a change feed, joined to hiring and public contract awards. Try it without a key on one sponsor.
Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "Metabolic and endocrine (diabetes, obesity) clinical trials: 8,439 open, 621 in phase 3", https://arcadiumdata.io/clinical-trials/area/metabolic-endocrine/, data as of 2026-10-25.