Gastroenterology and liver: clinical-trial pipeline
36,022 gastroenterology and liver trials are in ClinicalTrials.gov and the EU CTIS portal; 8,389 are not yet finished and 665 of those are in phase 2/3 or 3. Source: Arcadium Data, data as of .
Open trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 4,733 |
| Phase 2 | 1,364 |
| Phase 1 | 671 |
| Phase 3 | 541 |
| Phase 1/2 | 442 |
| Phase 4 | 376 |
| Early phase 1 | 138 |
| Phase 2/3 | 124 |
Sponsors with the most open trials
Recently changed open trials
| Registry id | Title | Sponsor | Phase | Status | Countries |
|---|---|---|---|---|---|
| NCT06304597 | Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy | University Medical Center Groningen | Phase 1 | Recruiting | Netherlands |
| NCT05076175 | A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcera… | Bristol-Myers Squibb | Phase 2/3 | Recruiting | Australia, Belgium, Canada, Germany +9 |
| NCT03847428 | Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Pa… | AstraZeneca | Phase 3 | Recruiting | Austria, Australia, Brazil, Canada +19 |
| NCT06426160 | Tocilizumab for Painful Chronic Pancreatitis | Aalborg University Hospital | Phase 2 | Active, not recruiting | Denmark |
| NCT06191120 | FAPI Molecular Imaging for Diagnosis of the CMS4 Unfavorable Colorectal Cancer Subtype | UMC Utrecht | Not applicable | Recruiting | Netherlands |
| NCT05865743 | Perioperative SDD to Prevent Infectious Complications After Esophagectomy | Radboud University Medical Center | Phase 3 | Recruiting | Belgium, Netherlands |
| NCT05706129 | A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety,… | Lumara Bio Oncologics GmbH | Phase 1/2 | Recruiting | Australia, Belgium, France |
| 2023-510140-21-00 | Intraoperative Sufentanil and chronic postsurgical pain in non-major scheduled abdominal surgery | Centre Hospitalier Universitaire Amiens Picardie | Phase 4 | Recruiting | France |
| 2023-509761-21-00 | CARE : Impact of Regorafenib in combination with multimodal metronomic chemotherapy (cyclophosphamide, capeci… | Centre Hospitalier Regional Universitaire | Phase 3 | Recruiting | France |
| 2023-505278-13-00 | JAKIH « A phase 2 open-label single-arm trial of JAK1 inhibitor for the treatment of large inflammatory hepat… | Assistance Publique Hopitaux De Paris | Phase 2 | Active, not recruiting | France |
| NCT06451913 | Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in… | Biocodex | Phase 4 | Active, not recruiting | Czechia, Lithuania, Slovenia, Slovakia |
| NCT05846516 | A Study to Evaluate ATP150/ATP152/ATP162, VSV-GP154 and Ezabenlimab in Patients With Pancreatic Ductal Adenoc… | Boehringer Ingelheim | Phase 1 | Active, not recruiting | Switzerland, Germany, Spain, France +1 |
| NCT05462717 | Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant So… | Revolution Medicines, Inc. | Phase 1 | Active, not recruiting | Australia, Czechia, Spain, France +9 |
| NCT05176483 | Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors | Exelixis | Phase 1 | Recruiting | Austria, Australia, Belgium, Switzerland +9 |
| NCT02912949 | A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy) | Partner Therapeutics, Inc. | Phase 2 | Not yet recruiting | Austria, Belgium, Canada, Germany +14 |
| 2023-508849-40-00 | The efficacy of aprepitant for the prevention of postoperative nausea and vomiting after bariatric surgery. | University Of Tartu | Phase 4 | Active, not recruiting | Estonia |
| 2023-503316-33-00 | tislelizUMaB in canceR patients with molEcuLar residuaL disease (UMBRELLA) | Institut Gustave Roussy | Phase 3 | Recruiting | France |
| NCT06668727 | Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody (The SAMBA Study) | Aarhus University Hospital | Phase 1 | Recruiting | Germany, Denmark |
| NCT06488625 | Efficacy and Safety of Oral Controlled-Ileocolonic-Release Nicotinamide (CICR-NAM) in Patients With Mild to M… | University Hospital Schleswig-Holstein | Phase 2/3 | Recruiting | Germany |
| NCT06453317 | Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Col… | Medical University of Lodz | Phase 2 | Recruiting | Poland |
All areas: clinical-trial pipeline by sponsor.
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Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "Gastroenterology and liver clinical trials: 8,389 open, 665 in phase 3", https://arcadiumdata.io/clinical-trials/area/gastroenterology/, data as of 2026-10-25.