National Heart, Lung, and Blood Institute (NHLBI): clinical-trial pipeline
National Heart, Lung, and Blood Institute (NHLBI) is the sponsor of 1,143 clinical trials in ClinicalTrials.gov and the EU CTIS portal; 93 are not yet finished and 4 were first posted in the last 90 days. Source: Arcadium Data, data as of .
Trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 767 |
| Phase 2 | 156 |
| Phase 3 | 122 |
| Phase 1 | 56 |
| Phase 1/2 | 30 |
| Early phase 1 | 6 |
| Phase 4 | 5 |
| Phase 2/3 | 1 |
Trials by status
| Status | Trials |
|---|---|
| Completed | 994 |
| Recruiting | 66 |
| Terminated | 38 |
| Active, not recruiting | 21 |
| Withdrawn or not authorised | 10 |
| Unknown | 7 |
| Not yet recruiting | 6 |
| Suspended or halted | 1 |
Condition areas
| Area | Trials |
|---|---|
| Cardiovascular | 695 |
| Respiratory | 203 |
| Haematology | 150 |
| Metabolic and endocrine (diabetes, obesity) | 116 |
| Rare and genetic diseases | 102 |
| Oncology | 92 |
| Infectious disease and vaccines | 61 |
| Neurology | 54 |
| Immunology and rheumatology | 49 |
| Musculoskeletal | 21 |
| Women's health and obstetrics | 21 |
| Gastroenterology and liver | 14 |
Countries
| Country | Trials |
|---|---|
| United States | 527 |
| Canada | 6 |
| China | 2 |
| Belarus | 1 |
| Denmark | 1 |
| United Kingdom | 1 |
| Israel | 1 |
| India | 1 |
| Italy | 1 |
| Mali | 1 |
| Nigeria | 1 |
| Russia | 1 |
| Ukraine | 1 |
Latest changes
| Day | Change | Trial |
|---|---|---|
| 2026-10-20 | New trial posted | Metabolic Impact of VLCPUFA-Rich Fish Oil: A Clinical Study on Omega-3 Index Enhancement… |
| 2026-10-20 | New trial posted | Epcoritamab as Consolidative Therapy for Waldenstr(SqrRoot)(Delta)m Macroglobulinemia (WM… |
| 2026-09-08 | New trial posted | NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Us… |
| 2026-09-01 | New trial posted | Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Ref… |
Open trials
The 25 most recently changed open trials.
| Registry id | Title | Phase | Status | Countries |
|---|---|---|---|---|
| NCT00923507 | Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocyti… | Not applicable | Recruiting | United States |
| NCT01500733 | PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | Phase 2 | Active, not recruiting | United States |
| NCT05904093 | Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sic… | Phase 1 | Recruiting | United States |
| NCT05072483 | Natural History Study of CADASIL | Not applicable | Recruiting | United States |
| NCT05357482 | Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Di… | Phase 1/2 | Active, not recruiting | United States |
| NCT05675436 | Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease | Not applicable | Active, not recruiting | United States |
| NCT03331380 | Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate… | Not applicable | Recruiting | United States |
| NCT00106925 | Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants | Not applicable | Recruiting | United States |
| NCT00943514 | Natural History of Bronchiectasis | Not applicable | Recruiting | United States |
| NCT07428707 | Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib | Early phase 1 | Recruiting | United States |
| NCT00001975 | Study of Skin Tumors in Tuberous Sclerosis | Not applicable | Recruiting | United States |
| NCT06093867 | Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Tr… | Not applicable | Recruiting | United States |
| NCT03986034 | Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CL… | Phase 2 | Recruiting | United States |
| NCT00071045 | Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Fa… | Not applicable | Recruiting | United States |
| NCT02514083 | A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL | Phase 2 | Active, not recruiting | United States |
| NCT07102849 | Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study | Not applicable | Recruiting | United States |
| NCT00001529 | Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives | Not applicable | Recruiting | United States |
| NCT05403151 | Controls and Healthy Vasculature Initiative | Not applicable | Recruiting | United States |
| NCT07796373 | Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent… | Phase 2 | Not yet recruiting | United States |
| NCT01621594 | Evaluating New Radiation Techniques for Cardiovascular Imaging | Not applicable | Recruiting | United States |
| NCT07806149 | NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-L… | Not applicable | Not yet recruiting | United States |
| NCT00081523 | Natural History of Sickle Cell Disease | Not applicable | Recruiting | United States |
| NCT07137429 | Platelet Volunteers, Longitudinal and Multi-omic Study | Not applicable | Recruiting | United States |
| NCT02423070 | Genome Transplant Dynamics | Not applicable | Recruiting | United States |
| NCT07137455 | EDEN Intracardiac Electrogram Recording and Classifying System | Not applicable | Recruiting | United States |
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Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "National Heart, Lung, and Blood Institute (NHLBI) clinical trials: 93 open, 123 in phase 3", https://arcadiumdata.io/clinical-trials/sponsor/national-heart-lung-and-blood-institute-nhlbi/, data as of 2026-10-25.