Children's Oncology Group: clinical-trial pipeline
Children's Oncology Group is the sponsor of 447 clinical trials in ClinicalTrials.gov and the EU CTIS portal; 70 are not yet finished and 3 were first posted in the last 90 days. Source: Arcadium Data, data as of .
Open trials70
Phase 2/3 and 3111
Countries29
New in 90 days3
Trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 198 |
| Phase 3 | 108 |
| Phase 2 | 78 |
| Phase 1 | 45 |
| Phase 1/2 | 15 |
| Phase 2/3 | 3 |
Trials by status
| Status | Trials |
|---|---|
| Completed | 359 |
| Active, not recruiting | 35 |
| Recruiting | 31 |
| Withdrawn or not authorised | 12 |
| Not yet recruiting | 4 |
| Terminated | 4 |
| Suspended or halted | 2 |
Condition areas
| Area | Trials |
|---|---|
| Oncology | 387 |
| Dermatology | 32 |
| Nephrology and urology | 29 |
| Musculoskeletal | 26 |
| Rare and genetic diseases | 24 |
| Gastroenterology and liver | 13 |
| Haematology | 12 |
| Neurology | 9 |
| Ophthalmology | 9 |
| Cardiovascular | 8 |
| Infectious disease and vaccines | 7 |
| Women's health and obstetrics | 7 |
Countries
| Country | Trials |
|---|---|
| United States | 349 |
| Canada | 226 |
| Australia | 174 |
| Puerto Rico | 122 |
| New Zealand | 82 |
| Switzerland | 80 |
| Netherlands | 40 |
| Saudi Arabia | 13 |
| Israel | 9 |
| France | 3 |
| United Kingdom | 3 |
| Brazil | 2 |
| Germany | 2 |
| Spain | 2 |
| Ireland | 2 |
Latest changes
| Day | Change | Trial |
|---|---|---|
| 2026-09-30 | New trial posted | Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), A… |
| 2026-09-21 | New trial posted | A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors T… |
| 2026-09-15 | New trial posted | Testing the Addition of an Anti-Cancer Drug, Daraxonrasib, for Relapsed or Refractory Sol… |
Open trials
The 25 most recently changed open trials.
| Registry id | Title | Phase | Status | Countries |
|---|---|---|---|---|
| NCT03007147 | Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromos… | Phase 3 | Active, not recruiting | Austria, Australia, Belgium, Canada +18 |
| NCT04994132 | A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarc… | Phase 3 | Active, not recruiting | Australia, Canada, Puerto Rico, Saudi Arabia +1 |
| NCT04684368 | A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT | Phase 2 | Recruiting | Australia, Canada, New Zealand, United States |
| NCT03067181 | Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients… | Phase 3 | Recruiting | Australia, Canada, United Kingdom, India +5 |
| NCT04851119 | Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors | Phase 1/2 | Recruiting | United States |
| NCT04903080 | HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma | Phase 1 | Active, not recruiting | Canada, United States |
| NCT06410209 | A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Ac… | Phase 2 | Recruiting | Puerto Rico, United States |
| NCT05602194 | Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma | Phase 3 | Active, not recruiting | Canada, United States |
| NCT07819838 | Testing the Addition of an Anti-Cancer Drug, Daraxonrasib, for Relapsed or Refractory Solid Tumors With RAS M… | Phase 1/2 | Not yet recruiting | |
| NCT03533582 | Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Can… | Phase 3 | Active, not recruiting | Australia, Canada, New Zealand, Puerto Rico +2 |
| NCT03834961 | Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed… | Phase 2 | Active, not recruiting | Canada, United States |
| NCT05711667 | A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pedia… | Phase 3 | Recruiting | United States |
| NCT02402244 | Project: Every Child for Younger Patients With Cancer | Not applicable | Recruiting | Australia, Canada, New Zealand, Puerto Rico +2 |
| NCT06647953 | Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Additi… | Phase 3 | Recruiting | Canada, United States |
| NCT02724579 | Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT… | Phase 2 | Active, not recruiting | Australia, Canada, Puerto Rico, Saudi Arabia +1 |
| NCT04385277 | Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozo… | Phase 2 | Active, not recruiting | Australia, Canada, New Zealand, United States |
| NCT06247787 | A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients Wi… | Phase 1 | Recruiting | United States |
| NCT04258943 | Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myelo… | Phase 1/2 | Active, not recruiting | Switzerland, Germany, Spain, France +4 |
| NCT03817398 | Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chro… | Phase 2 | Active, not recruiting | Australia, Canada, Puerto Rico, United States |
| NCT02521493 | Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in… | Phase 3 | Active, not recruiting | Australia, Canada, New Zealand, Puerto Rico +2 |
| NCT05702645 | A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia | Not applicable | Recruiting | Canada, United States |
| NCT04158739 | Flotetuzumab for the Treatment of Pediatric Recurrent or Refractory Acute Myeloid Leukemia | Phase 1 | Active, not recruiting | United States |
| NCT02176967 | Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neurobl… | Phase 3 | Active, not recruiting | Australia, Canada, New Zealand, Puerto Rico +2 |
| NCT03126916 | Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (… | Phase 3 | Recruiting | Canada, Puerto Rico, United States |
| NCT07621614 | A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and G… | Phase 2 | Recruiting | United States |
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Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "Children's Oncology Group clinical trials: 70 open, 111 in phase 3", https://arcadiumdata.io/clinical-trials/sponsor/children-s-oncology-group/, data as of 2026-10-25.