Ophthalmology: clinical-trial pipeline
12,963 ophthalmology trials are in ClinicalTrials.gov and the EU CTIS portal; 2,270 are not yet finished and 240 of those are in phase 2/3 or 3. Source: Arcadium Data, data as of .
Open trials by phase
| Phase | Trials |
|---|---|
| Not applicable | 1,455 |
| Phase 3 | 214 |
| Phase 2 | 187 |
| Phase 4 | 155 |
| Phase 1/2 | 105 |
| Phase 1 | 88 |
| Early phase 1 | 40 |
| Phase 2/3 | 26 |
Sponsors with the most open trials
| Sponsor | Type | Open trials | Phase 3 | Countries |
|---|---|---|---|---|
| Zhongshan Ophthalmic Center, Sun Yat-sen University | academic | 43 | 1 | 1 |
| Shanghai Eye Disease Prevention and Treatment Center | other | 28 | 0 | 1 |
| Assiut University | academic | 25 | 0 | 10 |
| The Hong Kong Polytechnic University | academic | 23 | 0 | 8 |
| Sohag University | academic | 23 | 0 | 5 |
| Second Affiliated Hospital, Zhejiang University, School of Medicine | academic | 19 | 0 | 5 |
| Beijing Tongren Hospital | academic | 19 | 0 | 1 |
| National Eye Institute (NEI) | government | 18 | 0 | 13 |
| Medical University of Vienna | academic | 18 | 0 | 31 |
| Essilor International | industry | 18 | 0 | 11 |
| Fondation Ophtalmologique Adolphe de Rothschild | academic | 16 | 1 | 2 |
| Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | academic | 16 | 0 | 1 |
| Eye & ENT Hospital of Fudan University | academic | 16 | 0 | 1 |
| Allergan | industry | 15 | 5 | 69 |
| Sun Yat-sen University | academic | 15 | 2 | 5 |
| Duke University | academic | 15 | 0 | 47 |
| Jaeb Center for Health Research | other | 15 | 5 | 16 |
| Stanford University | academic | 14 | 0 | 42 |
| Superior University | academic | 14 | 0 | 1 |
| Alcon Research | industry | 13 | 2 | 29 |
| Singapore National Eye Centre | government | 13 | 2 | 3 |
| National Taiwan University Hospital | academic | 13 | 0 | 4 |
| University of California, San Francisco | academic | 13 | 0 | 55 |
| Assistance Publique - Hôpitaux de Paris | academic | 12 | 1 | 26 |
| SightGlass Vision, Inc. | industry | 12 | 0 | 3 |
Recently changed open trials
| Registry id | Title | Sponsor | Phase | Status | Countries |
|---|---|---|---|---|---|
| NCT05966493 | A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED | Glaukos Corporation | Phase 2 | Recruiting | Germany, Spain, France, Italy +1 |
| NCT05697861 | Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001 | Intellia Therapeutics | Not applicable | Recruiting | France, United Kingdom, New Zealand, Sweden |
| 2024-510946-15-00 | ORACLE: A long-term follow-up study to evaluate the safety of GT005 in participants with geographic atrophy,… | Novartis Pharma AG | Phase 1/2 | Active, not recruiting | Germany, Spain, France, Poland |
| NCT06007690 | A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-… | Aura Biosciences | Phase 3 | Active, not recruiting | Austria, Australia, Belgium, Canada +14 |
| 2023-510041-16-00 | Glaucoma Intensity Treatment Study – Intensive non-invasive glaucoma treatment vs conventional stepwise treat… | Region Vaesterbotten | Phase 4 | Active, not recruiting | Sweden |
| NCT06260709 | A Research Study to Look at Long-term Treatment With a Medicine Called NNC6019-0001 for People Who Have Heart… | Novo Nordisk A/S | Phase 2 | Active, not recruiting | Canada, Czechia, Germany, Spain +6 |
| NCT06128629 | MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (A… | Intellia Therapeutics | Phase 3 | Recruiting | Argentina, Austria, Australia, Belgium +23 |
| NCT04681417 | Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outco… | Institut Curie | Phase 2/3 | Recruiting | France |
| 2024-513662-18-00 | A phase 1/2, open-label, safety, tolerability and preliminary efficacy study of implantation into one eye of… | Centre D'Etude Des Cellules Souches | Phase 1/2 | Recruiting | France |
| NCT05003986 | Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases | Travere Therapeutics, Inc. | Phase 2 | Recruiting | Germany, Spain, United Kingdom, Italy +4 |
| NCT04936854 | Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease | Haukeland University Hospital | Phase 2 | Recruiting | Norway |
| NCT04794101 | Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in t… | MeiraGTx Ocular UK Ltd | Phase 3 | Active, not recruiting | Belgium, Canada, Switzerland, Denmark +7 |
| NCT05724446 | Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery… | Salvat | Phase 3 | Recruiting | Spain |
| NCT04292080 | Long-Term Analysis of DImethyl Fumarate, to Slow the Growth of Areas of Geographic Atrophy | Assistance Publique - Hôpitaux de Paris | Phase 2 | Not yet recruiting | France |
| 2023-509469-19-00 | A non-randomised, open-label, uncontrolled, multi-centre, phase IIIb study evaluating the safety and efficacy… | Alimera Sciences Europe Limited | Phase 3 | Not yet recruiting | Germany, Spain |
| 2024-515481-13-00 | Multicenter clinical trial to evaluate the safety and feasibility of allogeneic tissue engineered product (hu… | Red Andaluza De Diseno Y Traslacion De Terapias Avanzadas Fundacion Publica Andaluza Progreso Y Salud | Phase 1/2 | Active, not recruiting | Spain |
| 2024-513983-24-00 | EMMA - Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistan… | Centre Hospitalier Universitaire De Dijon | Phase 4 | Recruiting | France |
| NCT04657289 | A Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery Syste… | Hoffmann-La Roche | Phase 3 | Active, not recruiting | Argentina, Austria, Australia, Belgium +11 |
| 2024-515553-17-00 | Safety and efficacy of a bilateral single subretinal injection of rAAV.hCNGA3 in adult and minor patients wit… | Universitaetsklinikum Tuebingen AöR | Phase 1/2 | Active, not recruiting | Germany |
| NCT04902859 | Clonidine as Pain Relief During ROP Eye Examinations | Region Oerebro Laen | Phase 4 | Recruiting | Sweden |
All areas: clinical-trial pipeline by sponsor.
Track a sponsor's pipeline
The API returns the same trials by sponsor website, phase, status, condition and country with a change feed, joined to hiring and public contract awards. Try it without a key on one sponsor.
Sources: ClinicalTrials.gov (U.S. National Library of Medicine, public domain) and the EU Clinical Trials Information System public portal (European Medicines Agency), data as of 2026-10-25. A trial that one register cites in the other is shown once. Organisation-level data only: investigators, contact persons and site names are not stored, and a sponsor that could be a private person is withheld. Sponsor-to-website matches are made by name and can be wrong; check the register before relying on a record. Independent of the NLM, NIH and EMA.
Cite as: Arcadium Data, "Ophthalmology clinical trials: 2,270 open, 240 in phase 3", https://arcadiumdata.io/clinical-trials/area/ophthalmology/, data as of 2026-10-25.